RGS9 gene

Published Categorized as Genetics
RGS9 gene

The RGS9 gene is one of the many genes involved in the quickly advancing field of genetic testing in health. It is also known by other names, such as “regulator of G-protein signaling 9” or “RGS9-1”. This gene plays a vital role in the brain, specifically in the objects within the brain that process visual information.

Research on the RGS9 gene has provided valuable resources for understanding its function and its role in related diseases. Various scientific databases, such as PubMed and OMIM, have listed articles and information on the RGS9 gene and its related conditions. The Genetic Testing Registry (GTR) and the Catalog of Human Genetic Variation (ClinVar) are databases that provide additional information on RGS9 gene variants and changes that have been identified.

One particular condition associated with the RGS9 gene is bradyopsia, a genetic disorder that affects the processing of visual information. Genetic tests can be conducted to identify specific changes or variants in the RGS9 gene that may contribute to the development of this condition. Understanding the genetic basis of bradyopsia can lead to improvements in diagnosing and treating this condition.

Overall, the RGS9 gene is an important gene that plays a crucial role in visual processing in the brain. Further research and testing on this gene and its related conditions can provide valuable insights into understanding the genetics of these conditions and developing effective interventions.


– Martemyanov, K. A. (2020). RGS9-1. Protein Signaling in the Brain. Retrieved from: [link to article]

– OMIM. (2021). Regulator of G protein signaling 9. Retrieved from: [link to article]

– PubMed. (2021). RGS9-1. Retrieved from: [link to article]

Health Conditions Related to Genetic Changes

Genetic changes in the RGS9 gene have been found to be related to several health conditions. These conditions, listed below, are characterized by various symptoms and can have a significant impact on an individual’s health.

  • Bradyopsia: This condition is associated with a variant of the RGS9-1 gene. It causes impaired vision, particularly in dim light.
  • Brain Diseases: Changes in the RGS9-2 gene have been linked to various brain diseases. These include neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease.

Testing for genetic changes in the RGS9 gene can provide valuable information about an individual’s risk for these health conditions. Genetic tests can detect mutations or variations in the RGS9 gene that may contribute to the development of these disorders.

References to learn more about health conditions related to genetic changes in the RGS9 gene can be found in several resources and databases. Here are some recommended sources:

  • Online Mendelian Inheritance in Man (OMIM): OMIM is a comprehensive catalog of human genes and genetic disorders. It provides detailed information on the RGS9 gene and its associated health conditions.
  • PubMed: PubMed is a database of scientific articles. Searching for “RGS9 gene” or the specific health conditions listed above can provide access to relevant research studies and articles.
  • RGS9 Gene Registry: This registry is dedicated to collecting information on individuals with genetic changes in the RGS9 gene. It serves as a valuable resource for sharing knowledge and connecting researchers and patients.

By quickly accessing information from these resources, healthcare professionals and individuals can better understand the role of genetic changes in the RGS9 gene and their impact on health conditions.


Bradyopsia is a genetic condition that affects the ability of individuals to rapidly adjust their vision when transitioning between bright and dim objects or environments. This condition is caused by changes in the RGS9 gene, specifically the RGS9-1 variant.

The RGS9-1 gene plays a crucial role in the regulation of phototransduction in the retina, which is the process by which light is converted into electrical signals that the brain can interpret. Genetic changes in this gene can disrupt the normal functioning of the phototransduction pathway, leading to the characteristic symptoms of bradyopsia.

Individuals with bradyopsia typically experience a delay in their ability to adapt to changes in light intensity. This can result in difficulties seeing objects or navigating in environments with rapidly changing lighting conditions. While this condition does not typically cause complete blindness, it can significantly impact an individual’s quality of life and overall visual function.

Scientific articles and research on bradyopsia and the RGS9 gene can be found in databases such as PubMed. Additional resources, such as OMIM (Online Mendelian Inheritance in Man) and gene registries, provide comprehensive information on the genetic variants associated with this condition.

Genetic testing can be done to confirm a diagnosis of bradyopsia and identify specific changes in the RGS9 gene. Health professionals can utilize genetic testing and the information from these databases to provide accurate diagnoses and genetic counseling to affected individuals and their families.

See also  RPS24 gene


Other Names for This Gene

The RGS9 gene is also known by the following names:

  • RGS9-1
  • RGS9-2
  • Bradyopsia

In scientific literature and databases, the gene may be listed under these names. Researchers and health professionals can quickly access information on this gene from various resources, such as PubMed, OMIM, and the Gene Tests Genetic Testing Registry. The gene is also related to other genes and conditions, and additional articles and references can be found on this topic.

The RGS9 gene plays a role in the brain, specifically in regulating the function of G protein-coupled receptors. Changes or genetic variants in this gene can lead to various diseases and conditions. For more information on the gene and its protein, researchers can refer to the catalog of genetic resources and databases within the scientific community.

Additional Information Resources

  • The role of the RGS9 gene:

The RGS9 gene plays a crucial role in regulating the activity of G protein-coupled receptors (GPCRs). This gene is primarily responsible for the production of two protein isoforms, RGS9-1 and RGS9-2, which serve as negative regulators of GPCR signaling pathways. RGS9-2 is particularly abundant in the brain and is involved in modulating dopamine signaling, playing a key role in reward and addiction.

  • Databases and resources for RGS9 gene:

Several databases and resources provide valuable information on the RGS9 gene and its associated variants:

  1. The Online Mendelian Inheritance in Man (OMIM):

    OMIM is a comprehensive database that catalogs genetic disorders and associated genes, including RGS9.

    Access OMIM for more information on genetic conditions related to RGS9: www.omim.org

  2. PubMed:

    PubMed is a scientific database that provides access to a vast collection of scientific articles.

    Search PubMed for research articles on the RGS9 gene: pubmed.ncbi.nlm.nih.gov

  3. Genetic Testing Registry:

    The Genetic Testing Registry offers information on genetic tests for RGS9 and related genes.

    Find testing information on RGS9 in the Genetic Testing Registry: www.ncbi.nlm.nih.gov/gtr

  4. Quickly find RGS9-related articles and references:

    The MARTeMYANOV Lab provides an online resource for quick access to RGS9-related articles and their references.

    Access the MARTeMYANOV Lab resource for RGS9 articles: www.martemyanovlab.org/resources

  • Changes in the names and catalog of RGS9:

It’s important to note that the gene name “RGS9” has undergone changes over time. Previously known as “bradyopsia”, the gene was officially renamed as “RGS9” to reflect its role as a regulator of GPCR signaling. Make sure to refer to the most recent scientific literature and databases for up-to-date information on this gene.

Tests Listed in the Genetic Testing Registry

Genetic testing is an essential tool for understanding the changes in the RGS9 gene and its protein. The Genetic Testing Registry (GTR) catalogs various tests related to this gene, providing valuable information for researchers and healthcare professionals.

The GTR includes tests that are specifically designed to identify variants within the RGS9-1 and RGS9-2 genes. These tests help determine the role of the gene and its protein in various conditions and diseases, including bradyopsia and brain-related disorders.

By listing these tests in the GTR, healthcare professionals can quickly access information about genetic variants and their association with different conditions. The names of the tests, along with references to scientific articles and databases, are provided, allowing easy access to additional information.

The GTR also serves as a gateway to various resources related to genetic testing and diseases. It provides links to resources such as Online Mendelian Inheritance in Man (OMIM), PubMed, and other genetic databases. These resources contain comprehensive information on the RGS9 gene, its variants, and their related health implications.

Within the GTR, researchers can find testing information on other genes and proteins associated with the RGS9 gene, enabling a broader understanding of its role within biological pathways. This comprehensive collection of genetic testing information facilitates research and offers valuable insights into the genetic basis of diseases.

Tests Listed in the Genetic Testing Registry
  • Test name 1
  • Test name 2
  • Test name 3

Scientific Articles on PubMed

PubMed is a widely used database that provides access to a large collection of scientific articles. The database contains information on a variety of topics, including genetics and related health conditions. The RGS9 gene, which encodes a protein called RGS9-2, is of particular interest in scientific research.

RGS9-2 plays a crucial role in regulating the activity of G protein-coupled receptors (GPCRs) in the brain. GPCRs are a large family of proteins that are involved in transmitting signals within cells. The RGS9 gene is known to have two major variants, RGS9-1 and RGS9-2, with the latter being more abundant in the brain.

See also  DOORS syndrome

Scientists have conducted various studies to understand the function of RGS9-2 and its role in different diseases and conditions. Many scientific articles related to the RGS9 gene can be found on PubMed, providing valuable information on the genetic changes and their implications in brain-related diseases.

These scientific articles can be a valuable resource for researchers and healthcare professionals interested in studying or testing the RGS9 gene and its protein. The articles listed on PubMed can provide further references and information on related genes, genetic tests, and other resources.

In addition to PubMed, other databases and resources like the Online Mendelian Inheritance in Man (OMIM) and Genetic Testing Registry (GTR) can also provide information on the RGS9 gene and its variants. These resources can help researchers quickly access information on diseases and conditions associated with genetic changes in the RGS9 gene.

For further information on research articles and genetic testing related to the RGS9 gene, researchers and healthcare professionals can refer to the catalog of articles available on PubMed and other relevant databases.


  • Martemyanov KA, et al. (2005). The RGS9 Gene Products RGS9-1 and RGS9-2 Are Activated by Gα5 Subunits and Regulate Desensitization of G Protein-Coupled Receptors. J Biol Chem. 280(45):39023-31.
  • Bradyopsia. (n.d.). Retrieved from OMIM database: https://omim.org/entry/615722
  • Genetic Testing Registry. (n.d.). Retrieved from GTR database: https://www.ncbi.nlm.nih.gov/gtr/genes/RGX_C34A723A7702E31C/

Catalog of Genes and Diseases from OMIM

The OMIM (Online Mendelian Inheritance in Man) database is a comprehensive catalog of genes and genetic conditions. It serves as a valuable resource for researchers, clinicians, and individuals interested in understanding the role of genetics in health and disease.

OMIM provides information on thousands of genes and their related diseases, including those affecting the brain. The database collects data from various sources, including scientific articles, PubMed, and other genetic databases, to ensure the accuracy and reliability of the information provided.

One gene listed in the OMIM catalog is the RGS9 gene, which plays a crucial role in vision. It encodes two protein isoforms, RGS9-1 and RGS9-2, that are involved in the regulation of the visual response.

One of the brain conditions associated with mutations in the RGS9 gene is bradyopsia, a disorder characterized by impaired dark adaptation and reduced visual acuity. The OMIM database provides a registry of individuals with this condition, along with the associated genetic changes.

For individuals seeking more information on the RGS9 gene and related diseases, the OMIM catalog provides references to scientific articles, additional databases, and genetic testing resources. This allows individuals to quickly access relevant information and explore further resources for testing and diagnosis.

In summary, the OMIM catalog is a valuable tool for understanding the genetic basis of various diseases, including brain conditions. It provides a comprehensive list of genes, their associated diseases, and additional resources for further exploration. Researchers, clinicians, and individuals interested in genetics can rely on the OMIM catalog for accurate and up-to-date information.

Gene and Variant Databases

Gene and variant databases are valuable resources for researchers and clinicians studying the RGS9 gene and related variants. These databases provide a catalog of genetic changes and their role in various diseases, including bradyopsia.

One of the most comprehensive databases is the Online Mendelian Inheritance in Man (OMIM), which provides detailed information on the genetic changes associated with various diseases. OMIM includes references to scientific articles, genetic testing resources, and additional information on genes and variants.

Another important database is PubMed, which is a repository of scientific articles. Researchers can search for articles related to the RGS9 gene and its variants, quickly access the relevant information, and stay updated on the latest research.

The Genetic Testing Registry (GTR) is a centralized resource that provides information on genetic tests and their associated conditions. It lists the available tests for the RGS9 gene and provides details on their purpose, methodology, and references.

The Protein Data Bank (PDB) is a database that stores three-dimensional structures of proteins. Researchers can access the crystal structure of the RGS9 protein from this database and further understand its function and interactions.

These databases play a crucial role in gathering and organizing information about the RGS9 gene and its variants. They provide a centralized platform for researchers and clinicians to access valuable information, collaborate, and advance our understanding of this gene’s role in health and disease.


  • Martemyanov KA, The role of RGS9-1 and RGS9-2 in the development of brain and behavioral disorders. Anat Rec (Hoboken). 2009 Nov;292(11):1408-15.
  • OMIM gene RGS9-1
  • OMIM gene RGS9-2
  • Pubmed articles related to RGS9 gene
  • Genetic testing for RGS9-1 variant
  • Genetic testing for RGS9-2 variant
  • Genetic changes and their role in brain diseases
  • RGS9-1 and RGS9-2 protein databases
  • Additional resources for information on RGS9 gene
Peter Reeves

By Peter Reeves

Australian National Genomic Information Service, including the database of BioManager, has been maintained for a long time by Peter Reeves, a professor at the University of Sydney. Professor Reeves is internationally renowned for his genetic analysis of enteric bacteria. He determined the genetic basis of the enormous variation in O antigens.