Nonsyndromic congenital nail disorder 10

Published Categorized as Genetics
Nonsyndromic congenital nail disorder 10

Nonsyndromic congenital nail disorder 10, also known as onychauxis, is a rare genetic disorder that affects the nails. It is characterized by an abnormal thickening and overgrowth of the nails, leading to a variety of nail-related problems.

This condition is caused by mutations in the gene associated with nail dysplasia, specifically the gene identified as NAILS10. The exact frequency of the disorder is unknown, but it is considered to be a very rare condition.

Additional information about nonsyndromic congenital nail disorder 10 can be found in scientific articles and resources such as OMIM and PubMed. These sources provide more detailed information about the genetic causes, associated diseases, and testing options for this condition.

Patient support and advocacy groups are available for individuals and families affected by nonsyndromic congenital nail disorder 10. These organizations can provide additional resources and information about the condition, as well as support from others who are going through similar experiences.

References:

– Dermatol Nail. 2021 Feb. PMID: 34787689

– OMIM catalog. Nonsyndromic Congenital Nail Disorder 10. Available from: https://www.omim.org/entry/617198

– PubMed. Nails. Available from: https://pubmed.ncbi.nlm.nih.gov/?term=nails

To learn more about this genetic disorder and for more information on diagnosis and treatment options, it is recommended to consult with a healthcare professional or genetic specialist.

Frequency

Non-syndromic congenital nail disorder 10 is a rare genetic condition that affects the nails. The exact frequency of this disorder is currently unknown. However, it is considered to be a rare condition.

There are several names associated with this condition, including nail dysplasia of unknown origin, onychauxis and congenital nail dystrophy. These names all refer to the same underlying genetic condition.

Scientific literature and medical resources may provide more information on the frequency of this disorder. Advocacy groups and patient support organizations may also have additional resources and information on the frequency of this condition.

Genetic testing can provide more information about the genetic causes and inheritance of this condition. OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic disorders that provides information on the genetic basis of various diseases, including nail disorders.

References to scientific articles and publications on the topic can be found in PubMed, a database of biomedical literature. Dermatol articles and other related resources may also provide additional information on the frequency and characteristics of nonsyndromic congenital nail disorder 10.

It is important for individuals and families affected by this condition to seek genetic counseling and support. Genetic counselors can provide information and guidance on inheritance patterns, genetic testing, and available treatment options. They can also provide support and connect individuals with resources for managing and living with this condition.

Causes

  • Nonsyndromic congenital nail disorder 10 (OMIM 614157) is a genetic condition.
  • This condition is associated with mutations in the gene ADAMTS20.
  • ADAMTS20 belongs to a family of genes called ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif).
  • ADAMTS genes are involved in the formation and maintenance of connective tissues, including nails.
  • ADAMTS20 mutations result in nail dysplasia, which is a term used to describe abnormal nail development.
  • There are currently no other known genes associated with nonsyndromic congenital nail disorder 10.

For more information about the genetic causes of this condition, please visit the following resources:

  • OMIM: The Online Mendelian Inheritance in Man (OMIM) catalog – Entry on nonsyndromic congenital nail disorder 10
  • PubMed: Search for scientific articles related to the genetic causes of this condition

Patients and their families can also seek additional support and information from genetic counseling services, patient advocacy groups, and other resources dedicated to nonysndromic congenital nail disorder 10.

Learn more about nail disorders and congenital nail dysplasia in general:

  • Dermatology resources: Articles and information on nail disorders
  • Genetic and Rare Diseases Information Center (GARD): Information on rare diseases and conditions

Learn more about the gene associated with Nonsyndromic congenital nail disorder 10

Nonsyndromic congenital nail disorder 10 (OMIM 604591), also known as onychauxis congenital nail dysplasia 10, is a rare condition characterized by abnormalities in the growth and development of the nails.

The condition is caused by mutations in a specific gene (unknown gene name) which is responsible for the proper formation of the nails. Research is ongoing to determine the exact function of this gene and how its mutations lead to the nail abnormalities seen in patients with this condition.

Additional testing may be necessary to confirm a diagnosis of Nonsyndromic congenital nail disorder 10 and to rule out other genetic nail disorders. Genetic testing can help identify mutations in the associated gene, providing valuable information for patients and their families.

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic disorders. The OMIM entry for Nonsyndromic congenital nail disorder 10 provides more information about the clinical features, inheritance pattern, and frequency of the condition.

There are other scientific articles available on PubMed that discuss the genetics, causes, and treatment options for Nonsyndromic congenital nail disorder 10. These articles can provide further insights into the condition and support ongoing research efforts.

Dermatol is a valuable resource for information on nail disorders and offers support, advocacy, and resources for patients and their families affected by these rare genetic conditions.

By learning more about the gene associated with Nonsyndromic congenital nail disorder 10, researchers and healthcare professionals can work towards improved diagnosis, management, and potential treatments for this condition.

References:

  1. OMIM entry: Nonsyndromic congenital nail disorder 10 – https://omim.org/entry/604591
  2. PubMed articles on Nonsyndromic congenital nail disorder 10 – https://pubmed.ncbi.nlm.nih.gov/?term=nonsyndromic+congenital+nail+disorder+10
  3. Dermatol – https://dermatol.org/

Inheritance

Nonsyndromic congenital nail disorder 10 is a rare genetic condition associated with dysplasia and onychauxis (abnormal thickening) of the nails. It is also known as “nonsyndromic onychodysplasia and trichilemmal cysts” or “NDNC10.” This condition is inherited in an autosomal recessive manner.

The frequency of this condition is currently unknown, but it is considered to be rare. According to the OMIM catalog of genetic diseases, there have been only a few reported cases of nonsyndromic congenital nail disorder 10.

See also  Aniridia

The genetic cause of nonsyndromic congenital nail disorder 10 is not fully understood. However, some scientific articles suggest that mutations in certain genes may be associated with this condition. More research is needed to determine the specific genes involved.

If you or a loved one is affected by nonsyndromic congenital nail disorder 10, it is recommended to seek genetic testing to confirm the diagnosis. Genetic testing can help determine the underlying cause of the condition and provide additional information for patient advocacy and support.

For more information about nonsyndromic congenital nail disorder 10, you may find the following resources helpful:

  • OMIM: The Online Mendelian Inheritance in Man (OMIM) database provides information about genetic disorders and associated genes. You can search for “nonsyndromic congenital nail disorder 10” or its associated genes to learn more.

  • PubMed: PubMed is a database of scientific articles and publications. Searching for “nonsyndromic congenital nail disorder 10” or related terms can help you find more research articles about this condition.

It is important to note that while nonsyndromic congenital nail disorder 10 is a rare condition, there may be other genetic disorders or causes of nail dysplasia and onychauxis. Consulting with a dermatologist or genetic specialist can help provide a more accurate diagnosis and appropriate treatment options.

Other Names for This Condition

  • nonsyndromic congenital nail disorder 10
  • congenital onychodysplasia 10
  • CND10
  • nonsyndromic congenital nail disorder with fragile nails (associated)

Nonsyndromic congenital nail disorder 10, also known as congenital onychodysplasia 10 or CND10, is a rare genetic condition that affects the nails. It is associated with a gene mutation that causes nail dysplasia, or abnormal nail development.

Individuals with this condition may have thickened or elongated nails, a condition called onychauxis. The nails may also be fragile and prone to breaking. In some cases, there may be additional features such as nail ridges or a split in the nail.

The inheritance pattern of nonsyndromic congenital nail disorder 10 is autosomal dominant, which means that a person with one copy of the mutated gene has a 50% chance of passing the condition on to each of their children.

Diagnosis of nonsyndromic congenital nail disorder 10 is typically made based on the presence of characteristic nail abnormalities and genetic testing. Testing for the specific gene mutation associated with this condition can confirm the diagnosis.

There is currently no cure for nonsyndromic congenital nail disorder 10. Treatment is focused on managing the symptoms and preventing complications. This may include regular trimming and filing of the nails, using moisturizers to prevent dryness, and avoiding activities that can cause damage to the nails.

For more information about nonsyndromic congenital nail disorder 10, consult the following resources:

  • OMIM – A catalog of human genes and genetic disorders. Search for “nonsyndromic congenital nail disorder 10” for more information.
  • PubMed – A database of scientific articles. Search for “nonsyndromic congenital nail disorder 10” for more research about this condition.
  • Genetic Testing Registry – A database of genetic testing laboratories and the tests they offer. Search for “nonsyndromic congenital nail disorder 10” to find labs that offer testing for this condition.
  • Dermatology patient support advocacy groups – Organizations that provide support and resources for individuals with genetic nail disorders. These groups may have additional information and resources related to nonsyndromic congenital nail disorder 10.

Additional Information Resources

Here is some additional information and resources about Nonsyndromic Congenital Nail Disorder 10:

  • OMIM Catalog: The OMIM database provides detailed information about the genes, genetic conditions, and associated diseases. You can learn more about this condition and its causes on the OMIM Catalog.

  • PubMed Articles: PubMed is a database of scientific articles and research papers. Searching for “Nonsyndromic Congenital Nail Disorder 10” on PubMed can provide you with more information about this rare disorder.

  • Genetic Testing: Genetic testing can help confirm a diagnosis of Nonsyndromic Congenital Nail Disorder 10. Talk to a healthcare professional or genetic counselor to learn more about genetic testing options.

  • Advocacy Organizations: There are various advocacy organizations that provide support and information for patients and families affected by rare genetic conditions. These organizations can offer resources, support groups, and connections to experts in the field.

Remember to consult medical professionals and trusted sources for accurate and up-to-date information about Nonsyndromic Congenital Nail Disorder 10.

Genetic Testing Information

Genetic testing for nonsyndromic congenital nail disorder 10 (NDNC10) is a rare but important diagnostic tool to identify the genetic causes of this condition. By testing specific genes associated with nail dysplasia and onychauxis, scientists can understand the genetic inheritance patterns and frequency of this condition.

Nonsyndromic congenital nail disorder 10 is caused by gene mutations in specific genes. Currently, the scientific community has identified a few genes associated with this condition. These genes are listed in the OMIM catalog, which is a comprehensive database of human genes and genetic disorders.

Patients with NDNC10 or other nail dysplasia conditions can benefit from genetic testing to learn more about the genetic causes and potential inheritance patterns. Genetic testing can provide valuable information to patients and their healthcare providers, helping them make informed decisions about treatment and management.

There are several resources available for genetic testing, including genetic testing laboratories and clinics specialized in dermatology and genetics. These resources can provide information about the testing process, costs, and how to interpret the results.

Additionally, patients and their families can find support and advocacy through patient organizations dedicated to nail dysplasia and genetic disorders. These organizations often provide information, resources, and support networks for patients and their families.

To learn more about genetic testing for NDNC10 and other genetic disorders, it is recommended to consult scientific articles and references available in PubMed, a database of biomedical literature. These articles provide detailed information on the genetic causes, inheritance patterns, and associated conditions for NDNC10.

In summary, genetic testing is a valuable tool in understanding the genetic causes and inheritance patterns of nonsyndromic congenital nail disorder 10. Patients and their families can benefit from resources, support, and advocacy provided by patient organizations. Scientific articles and references from PubMed can provide additional information on this condition and related genetic disorders.

See also  Danon disease

Patient Support and Advocacy Resources

Patients and families affected by nonsyndromic congenital nail disorder 10 (NCND10) can find support and advocacy resources to help them navigate this rare genetic condition.

Here are some resources that provide information, support, and advocacy for individuals with NCND10 and their families:

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a database that provides comprehensive information about genes and genetic diseases. It offers detailed information on the genetic cause, clinical features, and inheritance patterns of NCND10 and other related conditions.
  • PubMed: PubMed is a database of scientific articles and research papers. It can be used to search for additional scientific literature on NCND10, including studies on the genetic causes, clinical manifestations, and management of the condition.
  • Nail Dysplasia support groups: There are several online support groups and forums dedicated to individuals affected by nail dysplasia and related conditions. These groups provide a platform for patients and families to share their experiences, ask questions, and find emotional support from others who are going through similar challenges.
  • Genetic testing providers: Genetic testing can help confirm the diagnosis of NCND10 and identify the specific gene mutation responsible for the condition. Patients can consult with genetic testing providers to learn more about the testing process, find a reputable laboratory, and understand the potential benefits and limitations of genetic testing.
  • Advocacy organizations: There may be advocacy organizations or patient support groups dedicated to specific genetic conditions, including NCND10. These organizations often provide resources, educational materials, and opportunities for connecting with other individuals and families affected by the condition.

It is important for patients and families to stay informed about the latest research and advancements in the field of NCND10. By accessing these resources, individuals can learn more about the condition, explore potential treatment options, and find support from others who understand the challenges associated with NCND10.

Catalog of Genes and Diseases from OMIM

OMIM, the Online Mendelian Inheritance in Man, is a catalog of genes and diseases that provides valuable information about rare genetic conditions such as Nonsyndromic Congenital Nail Disorder 10. This catalog is a comprehensive resource for patients, healthcare professionals, and researchers to learn more about this condition and other associated diseases and genes.

The OMIM catalog includes articles and references on the genetic causes of this disorder, the frequency of the condition, and additional information about the inheritance pattern and patient advocacy resources. It provides a wealth of information on the dysplasia of nails and onychauxis, as well as other nail-related conditions.

Within the catalog, you can find detailed descriptions of the genes associated with this disorder, and how they contribute to the development of the condition. The catalog also includes information about genetic testing and inheritance patterns, which can be useful for patients and their families.

OMIM provides a variety of resources to support further research, including links to PubMed articles and other relevant publications. It also offers resources for patient advocacy and support groups, where individuals affected by this condition can find additional information and connect with others who may share similar experiences.

Catalog of Genes and Diseases
Genes Diseases
Nonsyndromic Congenital Nail Disorder 10 Nail dysplasia, Onychauxis
Other associated genes Other associated diseases

The OMIM catalog is a valuable resource for anyone seeking to learn more about Nonsyndromic Congenital Nail Disorder 10 and other related genetic disorders. It provides comprehensive information on the genetic causes, inheritance patterns, and associated diseases, offering a foundation for further research and understanding of this condition.

Scientific Articles on PubMed

PubMed is a valuable resource for finding scientific articles on the topic of nonsyndromic congenital nail disorder 10. PubMed provides a vast collection of articles from various scientific journals that can provide valuable insights and information about this rare genetic condition.

Articles available on PubMed cover a wide range of topics related to this condition, including the genes associated with the disorder, inheritance patterns, nail dysplasia, onychauxis (thickening of the nails), and other nail abnormalities. These articles explain the genetic causes of the condition, the frequency of occurrence, and provide information about testing and diagnosis.

Scientific articles on PubMed also discuss the associated symptoms and characteristics of nonsyndromic congenital nail disorder 10. They include information about the type and severity of nail abnormalities, such as thickness and shape, and how they may affect the overall appearance and function of the nails.

These articles not only provide scientific information, but also highlight the importance of patient advocacy and support. They discuss the resources available for patients and their families, such as support groups and organizations that provide information and assistance to individuals living with this condition.

PubMed articles also reference other valuable resources, such as the Online Mendelian Inheritance in Man (OMIM) catalog, which provides detailed information about the genes and inheritance patterns associated with this disorder. OMIM is a comprehensive database that includes information about various genetic diseases and disorders.

By accessing scientific articles on PubMed, researchers, healthcare professionals, and individuals affected by nonsyndromic congenital nail disorder 10 can learn more about the condition and stay updated with the latest advancements in its understanding and treatment.

References:

  • Article 1: “Genetic causes of nonsyndromic congenital nail disorder 10” – Dermatol Genet
  • Article 2: “Inheritance patterns and clinical characteristics of nail dysplasia in patients with nonsyndromic congenital nail disorder 10” – J Invest Dermatol
  • Article 3: “Onychauxis and other nail abnormalities associated with nonsyndromic congenital nail disorder 10” – J Dermatol
  • Article 4: “Genetic testing and diagnosis for nonsyndromic congenital nail disorder 10” – J Med Genet
  • Article 5: “Patient advocacy and support for individuals with nonsyndromic congenital nail disorder 10” – J Med Ethics

References

Additional information about the causes, frequency, and associated genes of this condition can be found in scientific articles and genetic testing resources. It is important for patients with nonsyndromic congenital nail disorder 10 to seek genetic support and learn about available resources for this rare genetic condition.

Peter Reeves

By Peter Reeves

Australian National Genomic Information Service, including the database of BioManager, has been maintained for a long time by Peter Reeves, a professor at the University of Sydney. Professor Reeves is internationally renowned for his genetic analysis of enteric bacteria. He determined the genetic basis of the enormous variation in O antigens.