ABCG2 gene

Published Categorized as Genetics
ABCG2 gene

The ABCG2 gene, also known as the ATP-binding cassette sub-family G member 2 gene, is listed in various genetic databases and resources. It is related to a group of genes that affect the ability of protein transport in the body. The gene has been linked to a number of conditions, including gout.

An additional variant of the ABCG2 gene has been identified, which causes changes in the protein’s function. This variant has been found to be associated with the development of gout and other related diseases. Testing for this variant can provide valuable information for scientific research and health monitoring.

Research articles on the ABCG2 gene can be found in the PubMed database. These articles provide insights into the genetic basis of diseases and the role of ABCG2 gene variants in various health conditions. The gene is included in the OMIM catalog, which is a comprehensive resource for genetic information.

Further research and testing on the ABCG2 gene and its variant are needed to better understand its impact on health and disease. The gene’s ability to transport substances in the body makes it an important target for studying various diseases and developing potential treatments.

For more information on the ABCG2 gene and related conditions, individuals can consult genetic testing laboratories, health professionals, and genetic counseling services. The gene may be included in genetic testing panels that assess the risk for certain diseases and provide personalized health recommendations based on individual genetic profiles.

Health Conditions Related to Genetic Changes

Genetic changes in the ABCG2 gene have been associated with several health conditions. Testing for these genetic changes can be helpful in determining the risk of certain diseases.


Gout is a common form of inflammatory arthritis that is caused by high levels of uric acid in the blood. Genetic changes in the ABCG2 gene can lead to a decreased ability to transport uric acid out of the body, resulting in increased levels of uric acid and an increased risk of gout.

Testing for genetic changes in the ABCG2 gene can be done to identify individuals who may be at an increased risk of developing gout. This information can be used to implement preventive measures and develop personalized treatment plans.

Other Health Conditions:

Genetic changes in the ABCG2 gene have also been linked to other health conditions such as cancer, heart disease, and drug response. The ABCG2 gene plays a role in the transport of various substances, including drugs and toxins, in the body. Genetic changes can affect the function of the ABCG2 protein, leading to altered drug response and an increased risk of certain diseases.

Additional resources, articles, and databases are available for further information on genetic changes in the ABCG2 gene and related health conditions. The Online Mendelian Inheritance in Man (OMIM) database, PubMed, and the Genetic Testing Registry are some of the valuable sources that provide scientific information on genes, variants, and associated diseases.


Genetic changes in the ABCG2 gene can have significant implications on an individual’s health. Testing for these changes can provide valuable information on the risk of certain diseases and guide personalized treatment approaches. It is important to stay informed about the latest research and scientific findings related to genetic changes and their impact on health conditions.


Gout is a type of arthritis that occurs when there is a buildup of uric acid in the blood. This can lead to the formation of needle-like crystals in the joints, causing swelling, redness, and severe pain.

The ABCG2 gene is one of the genes associated with gout. This gene codes for a protein that plays a role in the transport and release of uric acid. Certain genetic variants in the ABCG2 gene can result in decreased ability to transport uric acid out of the body, leading to elevated levels of uric acid in the blood and an increased risk of gout.

To determine if a person has a variant in the ABCG2 gene that increases their risk of gout, genetic testing can be performed. There are several databases and resources available that catalog genetic variants associated with gout and other diseases. These databases include OMIM, PubMed, and the Genetic Variant Registry, among others.

In addition to genetic testing, other tests such as blood tests can be done to measure uric acid levels in the blood. This can help diagnose gout and monitor treatment progress. Lifestyle changes, such as adopting a healthy diet and maintaining a healthy weight, can also help manage gout.

For more information on gout, its causes, and related health issues, there are numerous scientific articles and references available. These articles provide in-depth information on the role of genes, proteins, and transport mechanisms in gout development.


  • ABC transporters and gout. Pubmed.
  • OMIM entry for ABCG2 gene.
  • Genetic Variant Registry – gout gene variant information.

Overall, understanding the genetic variants and changes related to the ABCG2 gene can provide valuable insights into the development and management of gout. It is important to consult with healthcare professionals and access reliable scientific resources for accurate and up-to-date information on gout and other related diseases.

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Other Names for This Gene

  • ABCP
  • ATP-binding cassette, sub-family G (WHITE), member 2
  • BCRP
  • CDw338
  • EST157481
  • GOUT1
  • MRP2
  • MGC34429
  • MXR
  • Mitoxantrone resistance protein

The ABCG2 gene, also known as ATP-binding cassette, sub-family G (WHITE), member 2, has various names and aliases. These names are used to refer to this gene in different scientific, genetic, and health resources. The gene is associated with the ability to transport various substances, including drugs and other chemicals, across cell membranes.

The ABCG2 gene is listed under different names in various genetic databases and registries. Its aliases are often used to search for additional information, articles, and scientific references related to this gene. The gene has been studied for its role in several diseases and conditions, such as gout and blood disorders.

Understanding the different names and aliases associated with the ABCG2 gene can help researchers and health professionals access relevant resources and information. It allows for better communication and collaboration between scientists working on related genes and genetic causes of various conditions.

Additional Information Resources

Here is a list of additional resources that provide more information on the ABCG2 gene and related topics:

  • Catalog of Genetic Tests: A comprehensive catalog of genetic tests available for the ABCG2 gene.
  • References: A list of scientific papers and publications related to the ABCG2 gene.
  • Tests: Information on tests available for detecting changes in the ABCG2 gene.
  • Diseases: Information on diseases and conditions associated with variations in the ABCG2 gene.
  • Articles: Articles and news releases on the ABCG2 gene and its role in various diseases.
  • Databases: Online databases that provide information on the ABCG2 gene and related topics.

In addition to these resources, the following organizations and websites can provide further information on the ABCG2 gene:

  • OMIM: The Online Mendelian Inheritance in Man (OMIM) provides detailed information on genetic conditions and related genes.
  • PubMed: A database of scientific articles and publications on the ABCG2 gene and its functions.
  • Health Registry: A registry that collects information on individuals with ABCG2 gene variants and related health conditions.
  • Gene Variants Database: A database that provides information on different gene variants and their effects.
  • Testing Laboratories: Laboratories that offer genetic testing services for the ABCG2 gene and related genes.

These resources can help you learn more about the ABCG2 gene, its proteins, related genes, diseases and conditions, testing options, and other important information. It is important to consult these resources to stay up-to-date with the latest scientific findings and advancements in the field.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry (GTR) is a catalog of genetic tests and their associated information. It is freely available for use by healthcare professionals, researchers, and individuals seeking genetic testing information. This registry provides a central resource for finding information on genetic tests, including details on the genes, conditions, and variants that the tests examine.

The GTR releases a list of genetic tests on a regular basis, which includes information on the genes, variant names, and related conditions for each test. The release also includes links to scientific articles, databases, and other sources that provide additional information on the specific genes and their associated tests.

The GTR lists a wide range of tests related to the ABCG2 gene, which is known to be involved in the transport of various molecules across cell membranes. Genetic changes in this gene can lead to changes in the function of ABCG2 proteins, causing various diseases and conditions, such as gout and other blood-related disorders.

For each listed test, the GTR provides information on the specific genes and variants that are examined, as well as the conditions and diseases that the test can help identify. The registry also includes references to articles published in scientific journals, such as PubMed and OMIM, that provide further information on the genes and their associated tests.

Overall, the GTR serves as a valuable resource for healthcare professionals and researchers, providing comprehensive and up-to-date information on genetic tests and their relevance to various health conditions. By providing access to this information, the GTR contributes to the advancement of genetic research and the ability to diagnose and understand genetic disorders.

For more information on the tests listed in the Genetic Testing Registry, please visit the official GTR website.

Scientific Articles on PubMed

The ABCG2 gene is responsible for encoding a protein involved in the transport of various substances, including drugs, toxins, and other chemicals, in the body. It plays a significant role in drug resistance, and changes or variants in this gene can affect its ability to transport substances effectively.

For further understanding of the ABCG2 gene and its associated genetic variants, researchers can refer to scientific articles listed on PubMed. PubMed is a database that provides a registry of publications related to genetics, diseases, and other health conditions. By searching for the ABCG2 gene in PubMed, researchers can find a catalog of articles that provide valuable information on the gene’s functions, genetic changes, and their implications for various diseases.

These articles delve into the effects of specific variants of the ABCG2 gene, including their association with diseases such as gout. Researchers can find articles that investigate the causes and mechanisms by which these genetic changes contribute to the development of diseases.

In addition to information on the ABCG2 gene itself, PubMed also offers resources on related genes, proteins, and conditions. Researchers can find references to other genes and proteins involved in similar functions or pathways, as well as articles that discuss the interactions and relationships between these genes.

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PubMed provides a wealth of scientific articles on the ABCG2 gene, its variants, and related topics. Researchers can utilize the information available on this database to further explore the functions, effects, and potential therapeutic implications of the ABCG2 gene.

Catalog of Genes and Diseases from OMIM

The OMIM (Online Mendelian Inheritance in Man) catalog provides a comprehensive resource for genes and diseases. This catalog includes information on genes, their related diseases, and the genetic changes that cause these diseases.

The OMIM catalog contains a vast collection of genes and associated diseases. It serves as a valuable tool for researchers, healthcare professionals, and individuals interested in genetic testing and health conditions.

OMIM provides a registry of genes and diseases, listing the names and functions of each gene. It also provides information on the genetic changes that cause diseases, contributing to our understanding of the underlying causes and mechanisms of various conditions.

One of the major resources available on OMIM is the ability to search for genes and diseases. Users can search for specific genes or diseases using keywords and explore the related information available for each entry. This includes details on the proteins encoded by the genes and their functions.

The OMIM catalog also includes information on the variant forms of genes and diseases. For example, the ABCG2 gene has a variant related to gout. By studying these variants, researchers can gain insights into the genetic basis of specific conditions and develop diagnostic tests.

OMIM provides links to scientific articles and references related to each gene and disease, allowing users to access further information and stay updated with the latest research in the field. This ensures that users have access to the most current and relevant information when studying specific genes or diseases.

In conclusion, the OMIM catalog is a valuable resource for researchers, healthcare professionals, and individuals interested in genetic testing and health conditions. It offers a comprehensive collection of genes and diseases, along with information on their related genetic changes and causes. By providing access to this wealth of information, OMIM contributes to our understanding of various genetic conditions and supports the development of new diagnostic tests and therapies.

Gene and Variant Databases

In genetic research, databases play a crucial role in organizing and providing access to information related to genes and their variants. These databases collect and store data on genetic mutations, proteins, and other relevant information, enabling researchers and healthcare professionals to analyze and interpret genetic data.

Here is a list of some important databases that specialize in gene and variant information:

  • OMIM (Online Mendelian Inheritance in Man): A comprehensive catalog of genes and genetic conditions, OMIM provides information on the genetic causes of diseases and their related genes. It also includes references to scientific articles and resources for further reading.
  • dbSNP (Database of Single Nucleotide Polymorphisms): Maintained by the National Center for Biotechnology Information (NCBI), dbSNP is a database that documents single nucleotide variations in different species, including humans. It serves as a valuable resource for researchers studying genetic variations and their impact on health and diseases.
  • HGMD (Human Gene Mutation Database): HGMD is a comprehensive database of human gene mutations associated with inherited diseases. It provides detailed information on the genetic changes and their clinical implications, making it an essential resource for genetic testing and research.
  • ClinVar: ClinVar is a public database that collects and aggregates information on genetic variants and their clinical significance. It provides annotations on the impact of genetic changes on various diseases and offers a platform for sharing variant data among researchers and healthcare professionals.
  • gnomAD (Genome Aggregation Database): gnomAD is a population genetics database that catalogs genetic variation data from a diverse range of individuals. It provides extensive information on genetic variants found in different populations, allowing researchers to study the frequency and distribution of these variations.
  • ExAC (Exome Aggregation Consortium): Similar to gnomAD, ExAC is a database that compiles genetic variation data from exome sequencing studies. It is a valuable resource for researchers studying rare genetic diseases and variants.

These databases, among others, offer significant insights into the human genome and its variants. They serve as important references for understanding the genetic basis of diseases, facilitating research, and assisting in diagnostic testing and treatment decisions for various health conditions.


  1. ABC Transporter Gene Subfamily Structure
  2. ABCG2 gene: This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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  4. ABCG2 (BCRP) – ABC transporter database on the Transporter Classification Database
  5. ABC Transporter Family on the Human Genetic Variation Database
  6. ABCG2 – ATP binding cassette subfamily G member 2 on OMIM
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  11. ABCG2 gene – Genetics Home Reference
  12. Breast Cancer Resistance Protein (ABCG2) Mutations and Their Impact on Pharmacokinetics/Pharmacodynamics on PubMed
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  14. Gene – ABCG2 (assembly) on NCBI Assembly
  15. ABCG2 (BCRP) – Linked SNP/variant on NCBI dbSNP
  16. ABCG2 (BCRP) – Genetic Testing Registry on NCBI
  17. ABCG2 (BCRP) – Clinical testing on ClinGen
  18. ABCG2 (BCRP) – table on PharmGKB
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  21. ABC Transporters and Resistance to Antibiotics on MicrobeWiki
Peter Reeves

By Peter Reeves

Australian National Genomic Information Service, including the database of BioManager, has been maintained for a long time by Peter Reeves, a professor at the University of Sydney. Professor Reeves is internationally renowned for his genetic analysis of enteric bacteria. He determined the genetic basis of the enormous variation in O antigens.